Convalescent plasma in Covid-19: Possible mechanisms of action

M. Rojas; Y. Rodríguez; D. Monsalve; Y. Acosta-Ampudia; B. Camacho; J. Gallo; A. Rojas-Villarraga; C. Ramírez-Santana; J. Díaz-Coronado; R. Manrique; R. Mantilla; Y. Shoenfeld; J. Anaya

Статья

Convalescent plasma in Covid-19: Possible mechanisms of action

M. Rojas, Y. Rodríguez, D. Monsalve, Y. Acosta-Ampudia, B. Camacho, J. Gallo, A. Rojas-Villarraga, C. Ramírez-Santana, J. Díaz-Coronado, R. Manrique, R. Mantilla, Y. Shoenfeld, J. Anaya,

2021

https://doi.org/10.1016/j.autrev.2020.102554

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study. Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases. Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of a hypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality. © 2020 The Author(s)

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1. Version of Record от 2021-04-27

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Об авторах

M. Rojas
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
Y. Rodríguez
Clínica del Occidente, Bogota, Colombia
D. Monsalve
Instituto Distrital de Ciencia Biotecnología e Investigación en Salud, IDCBIS, Bogota, Colombia
Y. Acosta-Ampudia
Genoma CES, Universidad CES, Medellin, Colombia
B. Camacho
Fundación Universitaria de Ciencias de la Salud (FUCS), Bogota, Colombia
J. Gallo
Internal Medicine Department, Universidad CES, Medellin, Colombia
A. Rojas-Villarraga
Epidemiology and Biostatistics Research Group, Universidad CES, Medellin, Colombia
C. Ramírez-Santana
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Tel-Aviv University, Tel Aviv, Israel
J. Díaz-Coronado
Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russian Federation
R. Manrique
R. Mantilla
Y. Shoenfeld
J. Anaya

Название журнала

Autoimmunity Reviews

Том

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Ключевые слова

Fc receptor; immunoglobulin F(ab')2 fragment; neutralizing antibody; antiviral activity; B lymphocyte; complement activation; convalescence; coronavirus disease 2019; cytokine storm; dendritic cell; human; hypercoagulability; immunocompetent cell; immunomodulation; immunopathogenesis; nonhuman; plasma transfusion; Review; Severe acute respiratory syndrome coronavirus 2; T lymphocyte; Th1 cell; Th17 cell; virus etiology; virus neutralization; virus pathogenesis; Betacoronavirus; clinical trial (topic); Coronavirus infection; immunology; lymphocyte; pandemic; passive immunization; retrospective study; virus pneumonia; Antibodies, Neutralizing; Betacoronavirus; Clinical Trials as Topic; Coronavirus Infections; Humans; Immunization, Passive; Lymphocytes; Pandemics; Pneumonia, Viral; Retrospective Studies

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Elsevier B.V.

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Review

Тип лицензии Creative Commons

Правовой статус документа

Свободная лицензия

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scopus

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Статья

Convalescent plasma in Covid-19: Possible mechanisms of action

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