Поиск по репозиторию
Статья
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19
2021
Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to severe acute respiratory distress. The severity of the illness can also extend from mild disease to life-threatening acute respiratory distress syndrome (ARDS). SARS-CoV-2 infection can also affect the gastrointestinal tract, liver and pancreatic functions, leading to gastrointestinal symptoms. Moreover, SARS-CoV-2 can cause central and peripheral neurological manifestations, affect the cardiovascular system and promote renal dysfunction. Epidemiological data have indicated that cancer patients are at a higher risk of contracting the SARS-CoV-2 virus. Considering the multitude of clinical symptoms of COVID-19, the objective of the present review was to summarize their pathophysiology in previously healthy patients, as well as in those with comorbidities. The present review summarizes the current, though admittedly fluid knowledge on the pathophysiology and symptoms of COVID-19 infection. Although unclear issues still remain, the present study contributes to a more complete understanding of the disease, and may drive the direction of new research. The recognition of the severity of the clinical symptoms of COVID-19 is crucial for the specific therapeutic management of affected patients. © 2020 Elsevier Ltd
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Food and Chemical Toxicology
Том
- 146
Страницы
- -
Ключевые слова
- angiotensin converting enzyme 2; adult respiratory distress syndrome; Article; brain disease; cancer patient; cardiovascular system; cerebrovascular disease; coronary artery disease; coronavirus disease 2019; diabetes mellitus; disease severity; encephalitis; epilepsy; gastroenteritis; gastrointestinal disease; gastrointestinal tract; Guillain Barre syndrome; headache; heart failure; heart injury; hospital admission; human; hypertension; hypogeusia; hyposmia; kidney disease; malignant neoplasm; pandemic; pathophysiology; pneumonia; polyneuropathy; respiratory failure; respiratory system; Severe acute respiratory syndrome coronavirus 2; skin defect; smelling disorder; symptomatology; taste disorder; cardiovascular disease; comorbidity; complication; digestive system disease; drug therapy; female; kidney disease; lung disease; male; neoplasm; neurologic disease; pathophysiology; virology; Cardiovascular Diseases; Comorbidity; COVID-19; Digestive System Diseases; Female; Humans; Kidney Diseases; Lung Diseases; Male; Neoplasms; Nervous System Diseases; Pandemics; SARS-CoV-2
Издатель
- Elsevier Ltd
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
