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Статья
Isolation and phylogenetic analysis of SARS-CoV-2 variants collected in Russia during the COVID-19 outbreak
2021
Objectives: The outbreak of coronavirus disease 2019 (COVID-19) started in December 2019 in China and then spread worldwide over the following months, involving 188 countries. The objective of this study was to determine the molecular epidemiology of the COVID-19 outbreak in Russia. Methods: In this study, two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains were isolated and genetically characterized. A phylogenetic analysis of all available Russian sequences was then performed and these were compared to the epidemiological data on COVID-19 incidence to evaluate the molecular epidemiology and pattern of virus spread in the territory of Russia. Results and conclusions: Whole genome analysis of the isolates obtained in this study and 216 others isolated in Russia revealed a set of seven common mutations when compared to the original Wuhan virus, including amino acid substitutions in spike protein S and nucleoprotein N, possibly affecting their properties. Phylogenetic analysis of all Russian sequences and 8717 sequences from other countries showed multiple importations of the virus into Russia, local circulation, and several patterns of virus spread. © 2020 The Author(s)
Цитирование
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Версии
- 2. Corrected Version of Record от 2021-04-27
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- International Journal of Infectious Diseases
Том
- 99
Страницы
- 40-46
Ключевые слова
- protein S; RNA directed RNA polymerase; virus nucleoprotein; adult; amino acid substitution; Article; clinical article; coronavirus disease 2019; female; gene mutation; gene sequence; genetic variability; genome analysis; high throughput sequencing; human; immune response; male; molecular epidemiology; nonhuman; phylogeny; physical chemistry; protein structure; Russian Federation; Severe acute respiratory syndrome coronavirus 2; single nucleotide polymorphism; viral genetics; virus culture; virus isolation; virus transmission; whole genome sequencing; Betacoronavirus; Coronavirus infection; epidemic; genetics; pandemic; phylogeny; virology; virus genome; virus pneumonia; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Genome, Viral; Humans; Pandemics; Phylogeny; Pneumonia, Viral; Russia
Издатель
- Elsevier B.V.
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
