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Статья
Genomic epidemiology of the early stages of the SARS-CoV-2 outbreak in Russia
2021
The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use of phylogenetics to understand and control its spread. Here, we analyze the emergence of SARS-CoV-2 in Russia in March and April 2020. Combining phylogeographic analysis with travel history data, we estimate that the sampled viral diversity has originated from at least 67 closely timed introductions into Russia, mostly in late February to early March. All but one of these introductions were not from China, suggesting that border closure with China has helped delay establishment of SARS-CoV-2 in Russia. These introductions resulted in at least 9 distinct Russian lineages corresponding to domestic transmission. A notable transmission cluster corresponded to a nosocomial outbreak at the Vreden hospital in Saint Petersburg; phylodynamic analysis of this cluster reveals multiple (2-3) introductions each giving rise to a large number of cases, with a high initial effective reproduction number of 3.0 [1.9, 4.3]. © 2021, The Author(s).
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Nature Communications
Том
- 12
Выпуск
- 1
Страницы
- -
Ключевые слова
- disease incidence; disease transmission; epidemiology; genomics; phylogenetics; phylogeography; severe acute respiratory syndrome; article; China; nonhuman; reproduction; Russian Federation; Severe acute respiratory syndrome coronavirus 2; travel; basic reproduction number; epidemiology; genetics; human; mutation rate; phylogeography; Russian Federation; virus genome; whole genome sequencing; China; Russian Federation; Saint Petersburg; SARS coronavirus; Basic Reproduction Number; COVID-19; Genome, Viral; Humans; Mutation Rate; Phylogeography; Russia; SARS-CoV-2; Whole Genome Sequencing
Издатель
- Nature Research
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
