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Статья
Laboratory monitoring of COVID-19 patients and importance of coagulopathy markers [Лабораторный мониторинг COVID-19 и значение определения маркеров коагулопатии]
2021
The pandemic of a novel coronavirus infection COVID-19 has become a real challenge to the mankind and medical community and has raised a number of medical and social issues. Based on the currently available information on COVID-19 clinical cases, it follows that COVID-19 patients in critical condition exhibit a clinical picture of disseminated intravascular coagulation (DIC), septic shock with developing multiple organ failure, which justifies use of anticoagulant therapy in COVID-19 patients. In addition to isolating virus RNA from biological material and polymerase chain reaction diagnostics, use of simple and easily accessible laboratory blood markers is necessary for management of COVID-19 patients. If the activation of coagulation processes is sufficient enough, consumption of platelets and blood clotting factors can be diagnosed by laboratory methods as prolongation of routine blood clotting tests and increasing thrombocytopenia. Hyperfibrinogenemia, increased D-dimer level, prolonged prothrombin time, thrombocytopenia, lymphopenia, leukocytopenia, increased concentration of interleukin-6 and ferritin are observed in most COVID-19 patients. The degree of increase in these changes correlates with severity of the inflammatory process and serves as a prognostically unfavorable sign. Here we discuss value of laboratory monitoring playing an essential role in such pathological crisis that contributes to patient screening, diagnosis as well as further monitoring, treatment and rehabilitation. © 2020 Universidad de Antioquia. All rights reserved.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Obstetrics, Gynecology and Reproduction
Том
- 14
Выпуск
- 2
Страницы
- 132-147
Ключевые слова
- D dimer; fibrinogen; phospholipid antibody; procalcitonin; activated partial thromboplastin time; Article; blood brain barrier; blood clotting disorder; coronavirus disease 2019; disease severity; enzyme linked immunosorbent assay; human; hyperferritinemia; laboratory diagnosis; leukopenia; lymphocytopenia; nonhuman; patient monitoring; polymerase chain reaction; pregnant woman; prothrombin time; screening; serology; thrombocytopenia
Издатель
- IRBIS LLC
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
