Статья

Dynamics of coagulopathy in patients with different COVID-19 severity

A. Kalinskaya, O. Dukhin, I. Molodtsov, A. Maltseva, D. Sokorev, A. Elizarova, O. Sapozhnikova, K. Glebova, D. Stonogina, S. Shakhidzhanov, E. Nikonov, A. Mazus, I. Spiridonov, F. Ataullakhanov, L. Margolis, A. Shpektor, E. Vasilieva,
2020

With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications The goal of our present study was to evaluate which component of clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well as endogenous fibrinolysis in patients with COVID-19 correlates with the severity of the disease We prospectively included 58 patients with COVID-19 and 47 healthy volunteers as a control group that we recruited before the pandemic started It turns out that plasma coagulation with subsequent platelet aggregation, but not endothelial function, correlates with the severity of the COVID-19 IL-6 blockade may play a beneficial role in COVID-19 induced coagulopathy

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Версии

  • 1. Version of Record от 2020-07-04

Метаданные

Об авторах
  • A. Kalinskaya
    Moscow State University of Medicine and Dentistry
  • O. Dukhin
    Moscow State University of Medicine and Dentistry
  • I. Molodtsov
    Clinical City Hospital named after I.V. Davydovsky, Moscow Department of Healthcare
  • A. Maltseva
    Moscow State University of Medicine and Dentistry
  • D. Sokorev
    Moscow State University of Medicine and Dentistry
  • A. Elizarova
    Moscow State University of Medicine and Dentistry
  • O. Sapozhnikova
    Moscow State University of Medicine and Dentistry
  • K. Glebova
    Moscow State University of Medicine and Dentistry
  • D. Stonogina
    Moscow State University of Medicine and Dentistry
  • S. Shakhidzhanov
    Center for Theoretical Problems of Physico-Chemical Pharmacology RAS
  • E. Nikonov
    Russian National Research Medical University
  • A. Mazus
    Moscow City Center for AIDS Prevention and Control, Moscow Department of Healthcare
  • I. Spiridonov
    Center for Theoretical Problems of Physico-Chemical Pharmacology RAS
  • F. Ataullakhanov
    University of Pennsylvania
  • L. Margolis
    National Institutes of Health
  • A. Shpektor
    Moscow State University of Medicine and Dentistry
  • E. Vasilieva
    Moscow State University of Medicine and Dentistry
Предметная рубрика
  • COVID-19
Название журнала
  • medRxiv : the preprint server for health sciences
Тип документа
  • other
Тип лицензии Creative Commons
  • CC BY-ND
Правовой статус документа
  • Свободная лицензия
Источник
  • lens