Our research goal was to assess expected efficiency of «Clean air» Federal project with its activities aimed at reducing ambient air contamination and population health risks. We revealed that finding solutions to the project tasks on emissions reduction that had been set without taking into account peculiarities of city design, development, landscapes, meteorological conditions, and other factors, would not result in improved ambient air quality. Road and transport systems are to be modernized basing on transport flows modeling and application of calculations taking into account transport flows structure, speed, and intensity as well as some other parameters. Analysis of standardized death rate (SDR) in 2000-2018 revealed the highest total mortality in Chita against a reference city, Lipetsk; mortality due to respiratory diseases was higher in Bratsk, Krasnoyarsk, Magnitogorsk, Nizhniy Tagil, Novokuznetsk, Omsk, Chelyabinsk, Cherepovets, and Chita. Mortality caused by these diseases has been going down since 2007; starting from 2013, the highest mortality due to respiratory diseases has been registered in Krasnoyarsk. Long-term annual average SDR due to neoplasms is rather chaotic in most cities but it is persistently higher than in Lipetsk, the reference city; asymptomatic parameter (p