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Статья
Иммунопатология и иммунофармакотерапия коронавирусной болезни 2019 (COVID-19): фокус на интерлейкин 6
2020
Пандемия коронавирусной болезни 2019 (COVID-19) привлекла более пристальное, чем прежде, внимание к проблемам иммунопатологии болезней человека, многие из которых нашли свое отражение при изучении иммуновоспалительных ревматических заболеваний (ИВРЗ). Развитие гипериммунной патологии, получившей название «синдром цитокинового шторма», к патогенетическим субтипам которого относят гемофагоцитарный лимфогистиоцитоз, синдром активации макрофагов и синдром высвобождения цитокинов, входит в число наиболее тяжелых осложнений иммуновоспалительных заболеваний или терапии злокачественных новообразований и может быть стадией прогрессирования COVID-19. В спектре цитокинов, принимающих участие в патогенезе синдрома цитокинового шторма, большое значение придается интерлейкину 6 (ИЛ6). Внедрение в клиническую практику моноклональных антител (мАТ), ингибирующих активность этого цитокина (тоцилизумаб, сарилумаб и др.), относится к числу крупных достижений в лечении ИВРЗ и критических состояний в рамках синдрома цитокинового шторма при COVID-19. В обзоре обсуждаются данные, касающиеся клинического и прогностического значения ИЛ6 и эффективности мАТ к ИЛ6-рецепторам и ИЛ6 и перспективы персонифицированной терапии синдрома цитокинового шторма при COVID-19.
Цитирование
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