Organoids in Translational Oncology

M. Tatullo; B. Marrelli; C. Benincasa; E. Aiello; I. Makeeva; B. Zavan; A. Ballini; D. De Vito; G. Spagnuolo

Статья

Organoids in Translational Oncology

M. Tatullo, B. Marrelli, C. Benincasa, E. Aiello, I. Makeeva, B. Zavan, A. Ballini, D. De Vito, G. Spagnuolo,

2020

https://doi.org/10.3390/jcm9092774

Translational medicine aims to translate the most promising preclinical research into clinical practice. Oncology is a continuously growing medical field: the scientific research on cancer biology is currently based on in vitro experiments, carried out on tissue culture plates (TCPs) and other 2D samples. In this context, 3D printing has greatly improved the biofabrication of new biological matrices that mimic the extracellular environments, which may characterize healthy from cancerous tissues. Organoids have recently been described in several reports on scientific literature. The term that better describes such organoids-based tumoral tissues is "tumoroids". Tumoroids are substantially "tumor-like organoids", typically deriving from primary tumors harvested from patients. This topical review aims to give an update on organoids applied in translational medicine, paying specific attention to their use in the investigation of the main molecular mechanisms of cancer onset and growth, and on the most impacting strategies for effective targeted therapies.

Цитирование

Версии

1. Version of Record от 2020-08-27

Метаданные

Об авторах

M. Tatullo
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy;, danila.devito@uniba.it
B. Marrelli
Marrelli Health—Tecnologica Research Institute, Biomedical Section, Street E. Fermi, 88900 Crotone, Italy;, benedetta.marrelli@calabrodental.it, (B.M.);, caterina.benincasa@leverdipraterie.com, (C.B.);, elisa.aiello@tecnologicasrl.com, (E.A.)
C. Benincasa
Marrelli Health—Tecnologica Research Institute, Biomedical Section, Street E. Fermi, 88900 Crotone, Italy;, benedetta.marrelli@calabrodental.it, (B.M.);, caterina.benincasa@leverdipraterie.com, (C.B.);, elisa.aiello@tecnologicasrl.com, (E.A.)
E. Aiello
Marrelli Health—Tecnologica Research Institute, Biomedical Section, Street E. Fermi, 88900 Crotone, Italy;, benedetta.marrelli@calabrodental.it, (B.M.);, caterina.benincasa@leverdipraterie.com, (C.B.);, elisa.aiello@tecnologicasrl.com, (E.A.)
I. Makeeva
Department of Therapeutic Dentistry, Sechenov University Russia, 119146 Moscow, Russia;, irina.makeeva@libero.it, (I.M.);, gspagnuo@unina.it, (G.S.)
B. Zavan
Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy;, barbara.zavan@unife.it
A. Ballini
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, Campus Universitario “Ernesto Quagliariello”, 70125 Bari, Italy;, andrea.ballini@uniba.it, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
D. De Vito
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy;, danila.devito@uniba.it
G. Spagnuolo
Department of Therapeutic Dentistry, Sechenov University Russia, 119146 Moscow, Russia;, irina.makeeva@libero.it, (I.M.);, gspagnuo@unina.it, (G.S.), Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples, 80131 Naples, Italy

Название журнала

Journal of Clinical Medicine

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2774

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MDPI

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journal article

Тип лицензии Creative Commons

CC BY

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Свободная лицензия

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Статья

Organoids in Translational Oncology

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