COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Diffusion Capacity Abnormalities for Carbon Monoxide in Patients with COVID-19 At Three-Month Follow-up.

W. Qin, S. Chen, Y. Zhang, F. Dong, Z. Zhang, B. Hu, Z. Zhu, F. Li, X. Wang, Y. Wang, K. Zhen, J. Wang, Y. Wan, H. Li, I. Elalamy, C. Li, Z. Zhai, C. Wang,
2021
https://doi.org/10.1183/13993003.03677-2020

OBJECTIVE: To evaluate pulmonary function and clinical symptoms in coronavirus disease 2019 (COVID-19) survivors within 3 months after hospital discharge, and to identify risk factors associated with impaired lung function. METHODS AND MATERIAL: COVID-19 patients were prospectively followed up with pulmonary function tests and clinical characteristics for 3 months following discharge from a hospital in Wuhan, China between January and February 2020. RESULTS: 647 patients were included. 87 (13%) patients presented with weakness, 63 (10%) with palpitation and 56 (9%) with dyspnea. Prevalences of the three symptoms were markedly higher in severe patients than non-severe patients (19% versus 10% for weakness, p=0.003; 14% versus 7% for palpitation, p=0.007; 12% versus 7% for dyspnea, p=0.014). Results of multivariable regression showed an increased odd in the ongoing symptoms among severe patients (OR: 1.7, 95%CI: 1.1-2.6, p=0.026) or patients with longer hospital stay (OR: 1.03, 95%CI: 1.00-1.05, p=0.041). Pulmonary function test results were available for 81 patients, including 41 non-severe and 40 severe patients. In this subgroup, 44 (54%) patients manifested abnormal diffusion capacity for carbon monoxide (DLCO) (68% severe versus 42% non-severe patients, p=0.019). Chest CT total severity score (TSS)>10.5 (OR: 10.4; 95%CI: 2.5-44.1; p=0.001) on admission and ARDS (OR: 4.6; 95%CI: 1.4-15.5; p=0.014) were significantly associated with impaired DLCO. Pulmonary interstitial damage may be associated with abnormal DLCO. CONCLUSION: Pulmonary function, particularly DLCO, declined in COVID-19 survivors. This decrease was associated with TSS of chest CT >10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied DLCO.

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Версии

  • 1. Version of Record от 2021-02-11

Метаданные

Об авторах
  • W. Qin
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China., Drs Qin, Chen, Zhang, Dong and Zhang contributed equally as co-first authors.
  • S. Chen
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China., Drs Qin, Chen, Zhang, Dong and Zhang contributed equally as co-first authors.
  • Y. Zhang
    Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China., Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China., National Clinical Research Center for Respiratory Diseases, Beijing, China., Drs Qin, Chen, Zhang, Dong and Zhang contributed equally as co-first authors.
  • F. Dong
    Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China., Drs Qin, Chen, Zhang, Dong and Zhang contributed equally as co-first authors.
  • Z. Zhang
    Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China., Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China., National Clinical Research Center for Respiratory Diseases, Beijing, China., Drs Qin, Chen, Zhang, Dong and Zhang contributed equally as co-first authors.
  • B. Hu
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
  • Z. Zhu
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
  • F. Li
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
  • X. Wang
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
  • Y. Wang
    Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China., Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China., National Clinical Research Center for Respiratory Diseases, Beijing, China.
  • K. Zhen
    Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China., Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China., National Clinical Research Center for Respiratory Diseases, Beijing, China.
  • J. Wang
    Institute of Basic Research, Chinese Academy of Medical Sciences, Beijing, China.
  • Y. Wan
    Department of Radiology, Affiliated Hospital of Jianghan University, Wuhan, China.
  • H. Li
    Department of Radiology, Affiliated Hospital of Jianghan University, Wuhan, China.
  • I. Elalamy
    Hematology and Thrombosis Center, Tenon University Hospital, INSERM UMRS 938, Sorbonne University, Paris, France., The First I.M. Sechenov Moscow State Medical University, Moscow, Russia.
  • C. Li
    Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
  • Z. Zhai
    Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China., Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China., National Clinical Research Center for Respiratory Diseases, Beijing, China.
  • C. Wang
    Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China., Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China., National Clinical Research Center for Respiratory Diseases, Beijing, China., Peking Union Medical College, Chinese, Academy of Medical Sciences, Beijing, China.
Название журнала
  • European Respiratory Journal
Страницы
  • 2003677
Издатель
  • European Respiratory Society (ERS)
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • dimensions
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