Analysis of the pathways of the virus infiltration, the features of digestive lesions in COVID-19 and the search for an answer to the dilemma: Is the digestive system affected by this viral infection the cause or consequence? - allowed us to formulate a hypothesis about the possibility of developing a safe and effective oral vaccine against SARS-Cov-2. This paper substantiated the hypothesis. In our opinion, the oral vaccine against SARS-Cov-2 is likely to be the safest, even with the use of an attenuated strain of the virus.