Pri lechenii mul'timorbidnykh patsiyentov s tyazhelym techeniyem novoy koronavirusnoy infektsii, vyzvannoy virusom SARS-CoV-2 (COVID-19), neobkhodimo proyavlyat' vnimaniye k vozmozhnomu razvitiyu lekarstvennoy ekzantemy (LE) v lyuboy period vremeni lecheniya. Predstavleno klinicheskoye nablyudeniye bol'noy 92 let s tyazhelym techeniyem podtverzhdennogo PTSR SOVID-19. Na fone lecheniya amoksitsillinom/klavulanovoy kislotoy, moksifloksatsinom, atsetiltsisteinom, omeprazolom, enoksaparinom natriya na 9-y den' lecheniya poyavilis' umerenno zudyashchiye makuleznyye vysypaniya s tendentsiyey k sliyaniyu bez otritsatel'noy dinamiki somaticheskogo statusa. Na 15-y den' lecheniya na fone priyema deksametazona i khloropiramina kozhnyye vysypaniya regressirovali. Poyavleniye sypi mozhet byt' obuslovleno primeneniyem b-laktamnykh antibakterial'nykh preparatov i ftorkhinolonov, prisoyedineniyem bakterial'noy infektsii i immunnosupressivnym statusom patsiyentki starcheskogo vozrasta, a takzhe vysokoy virusnoy nagruzkoy, assotsiirovannoy s poyavleniyem dermatologicheskikh simptomov. Otsrochennoye poyavleniye kozhnykh izmeneniy na fone COVID-19 vozmozhno rassmatrivat' kak «marker» tyazhesti zabolevaniya.