The multinational corporations intensify activities in worldwide. For example, Vietnam’s international integration has also changed rapidly with the trend of gradually entering the global supply chain and global value chain that help to create a powerful dynamic for national economic development. A part domestic enterprises is engaged either in outsourcing, or become a multinational corporations suppliers, but their role was unstable. The article also provides an overview of the unprecedented impacts of the COVID-19 pandemic on Vietnamese businesses, and the appropriate responses to reshape and strengthen corporations for processing and manufacturing industries. Special measures are given to be implemented at enterprises to prevent the risk of sickness among workers, including older workers.