Research background: The pandemic caused by COVID-19 is one of such situations that required urgent, anti-crisis solutions on organizing medical-care and support for the life of people. Special attention in scientific research of scientists from different countries is paid to medical workers, as the main participants in the elimination of the pandemic, whose external and internal working conditions have changed to a greater extent. Purpose of the article: to investigate factors those affect the well-being of health care workers in the workplace during the COVID-19 pandemic. Methods: The basis of the tools of empirical sociological research was the author’s method of studying 3 groups of factors that affect the well-being of employees: informing of the situation associated with the pandemic, changes in the nature and conditions of work; specifics of working in remote mode in connection with the pandemic. Findings & Value added: The study revealed the importance of informing employees about the situation, as well as a high level of its reliability and timeliness. The most significant changes in the work were the need to control contacts, the use of special protective equipment and the appearance of a large number of stressful factors. The main consequence of working in a pandemic environment, both for employees working in the previous mode and for employees working in remote mode – is a decrease in the level of material well-being. The study of the transformation of work in remote mode, in addition to technical parameters, showed deterioration in working conditions and communication.