Статья

Lethal Outcome of Leptospirosis in Southern Russia: Characterization of Leptospira Interrogans Isolated from a Deсeased Teenager

A. Samoilov, N. Stoyanova, N. Tokarevich, B. Evengard, E. Zueva, Y. Panferova, Y. Ostankova, E. Zueva, D. Valutite, E. Kovalev, A. Litovko, A. Goncharov, A. Semenov, K. Khafizov, V. Dedkov,
2020

This article describes a lethal case of leptospirosis that occurred in Southern Russia. The Leptospira strain was isolated and characterized using a microscopic agglutination test, MALDI-TOF mass spectrometry, targeted PCR, and high-throughput sequencing. We show that molecular and mass-spectrometry methods can be an alternative to conventional methods of leptospirosis diagnostics and Leptospira study, which require highly qualified staff and can be performed only at specialized laboratories. We also report the first whole genome of L. interrogans isolated in Russia.

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  • 1. Version of Record от 2020-06-01

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Об авторах
  • A. Samoilov
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.), Central Research Institute for Epidemiology, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 111123 Moscow, Russia;, kkhafizov@gmail.com
  • N. Stoyanova
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • N. Tokarevich
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • B. Evengard
    Department of Clinical Microbiology, Umeå University, 90187 Umeå, Sweden;, birgitta.evengard@umu.se
  • E. Zueva
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • Y. Panferova
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • Y. Ostankova
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • E. Zueva
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • D. Valutite
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • E. Kovalev
    Department of Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance in the Rostov Region, 344019 Rostov-on-Don, Russia;, kovalev@rpndon.ru
  • A. Litovko
    Center for Hygiene and Epidemiology in the Rostov Region, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 344029 Rostov-on-Don, Russia;, litovko.anna@yandex.ru, (A.R.L.);, goncharov.alyu@yandex.ru, (A.U.G.)
  • A. Goncharov
    Center for Hygiene and Epidemiology in the Rostov Region, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 344029 Rostov-on-Don, Russia;, litovko.anna@yandex.ru, (A.R.L.);, goncharov.alyu@yandex.ru, (A.U.G.)
  • A. Semenov
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.)
  • K. Khafizov
    Central Research Institute for Epidemiology, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 111123 Moscow, Russia;, kkhafizov@gmail.com
  • V. Dedkov
    Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia;, andrei.samoilov@gmail.com, (A.E.S.);, nat.stojanova@yandex.ru, (N.A.S.);, zoonoses@mail.ru, (N.K.T.);, elenazueva9@gmail.com, (E.V.Z.);, ersvart@inbox.ru, (Y.A.P.);, shenna1@yandex.ru, (Y.V.O.);, ezueva75@mail.ru, (E.B.Z.);, dianavalutite008@gmail.com, (D.E.V.);, alexvsemenov@gmail.com, (A.V.S.), Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, 119435 Moscow, Russia
Название журнала
  • International Journal of Environmental Research and Public Health
Том
  • 17
Выпуск
  • 12
Страницы
  • 4238
Издатель
  • MDPI
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
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