Статья

COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight

C. Auffray, R. Balling, N. Blomberg, M. Bonaldo, B. Boutron, S. Brahmachari, C. Bréchot, A. Cesario, S. Chen, K. Clément, D. Danilenko, A. Di Meglio, A. Gelemanović, C. Goble, T. Gojobori, J. Goldman, M. Goldman, Y. Guo, J. Heath, L. Hood, P. Hunter, L. Jin, H. Kitano, B. Knoppers, D. Lancet, C. Larue, M. Lathrop, M. Laville, A. Lindner, A. Magnan, A. Metspalu, E. Morin, L. Ng, L. Nicod, D. Noble, L. Nottale, H. Nowotny, T. Ochoa, I. Okeke, T. Oni, P. Openshaw, M. Oztürk, S. Palkonen, J. Paweska, C. Pison, M. Polymeropoulos, C. Pristipino, U. Protzer, J. Roca, D. Rozman, M. Santolini, F. Sanz, G. Scambia, E. Segal, I. Serageldin, M. Soares, P. Sterk, S. Sugano, G. Superti-Furga, D. Supple, J. Tegner, M. Uhlen, A. Urbani, A. Valencia, V. Valentini, S. van der Werf, M. Vinciguerra, O. Wolkenhauer, E. Wouters,
2020

Background : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to a subgroup of coronaviruses rampant in bats for centuries. It caused the coronavirus disease 2019 (COVID-19) pandemic. Most patients recover, but a minority of severe cases experience acute respiratory distress or an inflammatory storm devastating many organs that can lead to patient death. The spread of SARS-CoV-2 was facilitated by the increasing intensity of air travel, urban congestion and human contact during the past decades. Until therapies and vaccines are available, tests for virus exposure, confinement and distancing measures have helped curb the pandemic. Vision : The COVID-19 pandemic calls for safeguards and remediation measures through a systemic response. Self-organizing initiatives by scientists and citizens are developing an advanced collective intelligence response to the coronavirus crisis. Their integration forms Olympiads of Solidarity and Health. Their ability to optimize our response to COVID-19 could serve as a model to trigger a global metamorphosis of our societies with far-reaching consequences for attacking fundamental challenges facing humanity in the 21 st century. Mission : For COVID-19 and these other challenges, there is no alternative but action. Meeting in Paris in 2003, we set out to "rethink research to understand life and improve health." We have formed an international coalition of academia and industry ecosystems taking a systems medicine approach to understanding COVID-19 by thoroughly characterizing viruses, patients and populations during the pandemic, using openly shared tools. All results will be publicly available with no initial claims for intellectual property rights. This World Alliance for Health and Wellbeing will catalyze the creation of medical and health products such as diagnostic tests, drugs and vaccines that become common goods accessible to all, while seeking further alliances with civil society to bridge with socio-ecological and technological approaches that characterise urban systems, for a collective response to future health emergencies.

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  • 1. Version of Record от 2020-09-14

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Об авторах
  • C. Auffray
    European Institute for Systems Biology & Medicine, EISBM, Vourles, 69390, France
  • R. Balling
    Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, L-4362, Luxembourg
  • N. Blomberg
    ELIXIR, Wellcome Genome Campus, Hinxton, CB10 1SD, UK
  • M. Bonaldo
    Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro, RJ 21040-360, Brazil
  • B. Boutron
    European Institute for Systems Biology & Medicine, EISBM, Vourles, 69390, France
  • S. Brahmachari
    Institute of Genomics and Integrative Biology, CSIR, Delhi, 110 007, India
  • C. Bréchot
    Global Virus Network, University of South Florida, Tampa, FL, 33612, USA
  • A. Cesario
    Fondazione Policlinico Universitario “A. Gemelli” - IRCCS, Rome, 00168, Italy, Italian Association for Systems Medicine and Healthcare - ASSIMSS, Rome, Italy
  • S. Chen
    National Research Center for Translational Medicine, Jiao Tong University School of Medicine, Shanghai, 200025, China
  • K. Clément
    Nutriomique Research Unit, F-CRIN/FORCE network, Pitié-Salpêtrière Hospital, Paris-Sorbonne University, Paris, 75013, France
  • D. Danilenko
    Smorodintsev Research Institute of Influenza, Saint-Petersburg, 197376, Russian Federation
  • A. Di Meglio
    CERN, Meyrin, 1217, Switzerland
  • A. Gelemanović
    Mediterranean Institute for Life Sciences, Split, 21000, Croatia
  • C. Goble
    Department of Computer Science, University of Manchester, Manchester, M13 9PL, UK
  • T. Gojobori
    Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, 4700, Saudi Arabia, National Institute of Genetics, Mishima, 411-8540, Japan
  • J. Goldman
    Infectious Diseases and Organ Transplant, Swedish Medical Group, Providence St Joseph Health, Seattle, WA, 98104, USA
  • M. Goldman
    Institute for Interdisciplinary Innovation in Healthcare, Université Libre de Bruxelles, Brussels, 1050, Belgium
  • Y. Guo
    Data Science Institute, Imperial College London, London, SW7 2AZ, UK, President Office, Hong Kong Baptist University, Kowloon, Hong Kong
  • J. Heath
    Institute for Systems Biology, Seattle, WA, 98109, USA
  • L. Hood
    Institute for Systems Biology, Seattle, WA, 98109, USA, Providence St Joseph Health, Seattle, WA, 98104, USA
  • P. Hunter
    Auckland Bioengineering Institute, The University of Auckland, Auckland, 1142, New Zealand
  • L. Jin
    Human Phenome Institute, Fudan University, Shanghai, 201203, China
  • H. Kitano
    Systems Biology Institute, Tokyo, 141-0022, Japan, Okinawa Institute of Science and Technology Graduate University, Okinawa, 904-0495, Japan
  • B. Knoppers
    Centre of Genomics and Policy, Faculty of Medicine, Human Genetics, McGill University, Montréal, Québec, H3A 0G4, Canada
  • D. Lancet
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610010, Israel
  • C. Larue
    Integrated Biobank of Luxembourg, Luxembourg Institute of Health, Dudelange, L-3555, Luxembourg
  • M. Lathrop
    McGill Genome Centre, McGill University, Montréal, Québec, H3A 0G1, Canada
  • M. Laville
    Lyon-Sud University Hospital, Pierre-Bénite, 69310, France
  • A. Lindner
    Center for Research and Interdisciplinarity, Université de Paris, Paris, 75004, France
  • A. Magnan
    L'institut Du Thorax, Faculté de Médecine, Université de Nantes, Nantes, 44007, France
  • A. Metspalu
    Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia
  • E. Morin
    Association pour la Pensée Complexe, Montpellier, 34000, France
  • L. Ng
    Singapore Immunology Network, A*STAR, Singapore, 139648, Singapore
  • L. Nicod
    Service de Pulmonologie, Centre Hospitalier Universitaire Vaudois, Lausanne, 1011, Switzerland
  • D. Noble
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3P, UK
  • L. Nottale
    Paris-Meudon Observatory, Meudon, 92190, France
  • H. Nowotny
    Vienna Science and Technology Fund, Wien, 1090, Austria
  • T. Ochoa
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
  • I. Okeke
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
  • T. Oni
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0SL, UK, School of Public Health and Family Medicine, University of Cape Town, Cape Town, 7925, South Africa
  • P. Openshaw
    Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, SW3 6LY, UK
  • M. Oztürk
    Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, 35340, Turkey
  • S. Palkonen
    Patient Access Partnership, Brussels, 1040, Belgium
  • J. Paweska
    Centre for Emerging Zoonotic and Parasitic Diseases, National Institute of Communicable Diseases, National Health Laboratory Service, Gauteng, South Africa
  • C. Pison
    Grenoble-Alps University Albert Michallon Hospital, La Tronche, 38700, France
  • M. Polymeropoulos
    Vanda Pharmaceuticals, Washington, DC, 20037, USA
  • C. Pristipino
    Italian Association for Systems Medicine and Healthcare - ASSIMSS, Rome, Italy, San Filippo Neri Hospital, Roma, 00135, Italy
  • U. Protzer
    Institute of Virology, Technical University of Munich / Helmholtz Zentrum München, Munich, 81675, Germany
  • J. Roca
    Thorax Clinical Institute, Hospital Clinic, Barcelona, Spain
  • D. Rozman
    Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia
  • M. Santolini
    Center for Research and Interdisciplinarity, Université de Paris, Paris, 75004, France
  • F. Sanz
    Research Programme on Biomedical Informatics, Institut Hospital de Mar de Investigaciones Mèdiques, Universitat Pompeu Fabra, Barcelona, E-08003, Spain
  • G. Scambia
    Fondazione Policlinico Universitario “A. Gemelli” - IRCCS, Rome, 00168, Italy
  • E. Segal
    Weizmann Institute of Science, Rehovot, Israel
  • I. Serageldin
    Library of Alexandria, Alexandria, 21526, Egypt
  • M. Soares
    University of Illinois College of Medicine, Peoria, IL, 61605, USA
  • P. Sterk
    Department of Pulmonary diseases, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands
  • S. Sugano
    Laboratory of Functional Genomics, Department of Medical Genome Sciences, University of Tokyo, Tokyo, 108-8639, Japan, University of Chiba, Chiba, 277-8562, Japan
  • G. Superti-Furga
    Research Center for Molecular Medicine, Medical University of Vienna, Wien, Austria
  • D. Supple
    Asthma-UK, London, E1 8AA, UK
  • J. Tegner
    Living Systems Laboratory, King Abdullah University of Science and Technology, Thuwal, 4700, Saudi Arabia, Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, 17176, Sweden
  • M. Uhlen
    Science for Life Laboratory, Royal Institute of Technology, Stockholm, SE-100 44, Sweden
  • A. Urbani
    Fondazione Policlinico Universitario “A. Gemelli” - IRCCS, Rome, 00168, Italy
  • A. Valencia
    Barcelona Supercomputing Center, Barcelona, 08034, Spain
  • V. Valentini
    Fondazione Policlinico Universitario “A. Gemelli” - IRCCS, Rome, 00168, Italy
  • S. van der Werf
    Department of Virology, Institut Pasteur, Paris, 75015, France
  • M. Vinciguerra
    International Clinical Research Center, St. Anne's University Hospital, Brno, 656 91, Czech Republic
  • O. Wolkenhauer
    Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, 18057, Germany
  • E. Wouters
    Department of Respiratory Medicine, University of Maastricht, Maastricht, 6200 MD, The Netherlands, Ludwig Boltzmann Institute for Lung Health, Vienna, A-1140, Austria
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