The paper deals with the situation of one of the most vulnerable social groups under COVID-19, namely migrants and refugees. The author classifies pandemic-related challenges faced by migrants into several groups: (1) economic, (2) medical, or sanitary-epidemiological, (3) socio-psychological, and (4) political. Special attention is paid to the situation in Russia, which largely coincides with what is happening in other countries with numerous numbers of migrants, and at the same time has its own specificity.