The strategy for the development of the supply chain should ensure a high level of fault tolerance of all links when exposed to adverse factors. The article analyzes the impact on the stability of the supply chain of two types of influences: failure and disruption. The low stability of the supply chain appears in the stoppage of work in case of any disruptions and failures. With moderate stability, disruptions do not give up a significant impact on the operation of the supply chain, and failures lead to an increase in operating costs to maintain the stability of work processes. With a high level of stability, failures can cause disruptions in the operations of individual links. In case of disruptions, response models are applied based on the control of process parameters, the subsequent analysis of the causes of disruptions and the development of measures to restore the normal operation of the links in the supply chain. Effective disruption response involves the use of proactive response models. For this, it is necessary to ensure flexibility and transparency of processes in all links of the supply chain based on digital services for material flow control and mining of big data.