The article discusses the problem of the neuropsychiatric health deterioration in the face of new challenges to humanity: the complication of the scientific and technical environment and the technosphere, social relations in society against the background of an increase in the duration of a person's active life, as well as the relevance of the development of neurorehabilitation technologies for restoring human health in these conditions. The paper presents a review of the evolution of the technology of transcutaneous neuroelectrostimulation from ancient times to modern technologies, transcranial electrical stimulation, electrical stimulation of cranial nerves, spinal cord and neck nerve structures. The prospects of a mobile hardware and software system for polyfactorial neurostimulation and its potential for use in personalized medicine are considered. Possibilities of promising medical technologies for homeostatic regulation, capable of modulating autonomic processes, influencing motor control and cognitive functions are discussed.