Lassa fever (LF) is an acute and sometimes fatal viral hemorrhagic fever caused by the Lassa virus (LASV). It is a major public health challenge and endemic exclusively in West Africa. Despite the large toll of human morbidity and mortality, no vaccine or effective drugs are available to treat this disease. Therefore, there is an urgent need for the development of novel and effective treatments and therapeutics. LASV nucleoprotein plays a vital role in several aspects of the viral life cycle. Therefore, an effective inhibitor of LASV nucleoprotein will potentially control the replication of LASV. To evaluate the inhibitory effect of Dandelion phyto-compounds on LASV nucleoprotein, Glide-SP, and – XP docking was performed for hit identification. The hit compounds were further subjected to Induced Fit Docking (IFD) followed by Prime MM-GBSA calculation and ADME studies. Dandelion phyto-compounds, carfentrazone, luteolin, caffeic acid, and riboflavin recorded better binding affinity than the reference drug, ribavirin, and interacted with key amino acids residues. ADME studies also showed that our hit compounds are drug-like. This study showed that phyto-compounds of dandelion could be a better and effective therapeutics in LF treatment.