Introduction. Experts in many occupations are to carry out their occupational activities in unusual conditions. And in particular, in a remote mode, which can be a factor that reduces the level of psychological well-being of the individual if there is no compliance with the situation of self-isolation. The purpose of the study is to study the teachers' compliance with the situation of self-isolation during the COVID-19 pandemic. The tasks of the study include the detection of the grade of the compliance with the situation of self-isolation during the pandemic, the analysis of the level of compliance with the situation of selfisolation during the pandemic as a factor of psychological well-being of teachers. Material and methods. We surveyed 124 teachers (between 23 to 67 years). The respondents' answers are represented on three scales: Understanding the situation of self-isolation', 'Understanding of oneself in the situation of isolation, 'Understanding the characteristics of the interactions and communication in the situation of isolation'. Results. Most respondents agree with the need for self-isolation and consider it to be a practical approach to prevent the incidence of COVID-19. The most pronounced responses are the ones on improving occupational and cultural levels. Most of the respondents note a high level of understanding of the value of relationships. Discussion. In particular, the problem of insufficiently high level of self-understanding in the situation of selfisolation, along with the acknowledgement of the need to comply with it, to be revealed. In this regard, it is advisable to provide psychological assistance in the form of information support for the population. Conclusion. That the better the respondents understand the need for self-isolation, the more effective the process of communication and interaction with others is, and, consequently, the less damage is caused to the level of psychological well-being of the individual. Due to the established lack of understanding of oneself in the situation of self-isolation, the following can be considered practical areas of informational psychological support: Critical attitude to information that appears in various sources; building positive relationships within the family; managing work at home to ensure good performance; preserving the ability to return to the usual mode of life after the period of self-isolation.