Background. Cancer patients comprise one of the most vulnerable subpopulations under COVID-19 pandemic, since the incidence of COVID-19 among cancer patients exceeds this value in general population. Risk of severe COVID-19 infection and mortality is higher in patients with cancer. Objective. Searching and retrospective analysis of risk factors of mortality in cancer patients with COVID-19 infection. Material and methods. A retrospective analysis included 31 cancer patients who underwent surgery at the Herzen Moscow Oncology Research Institute. COVID-19 was detected in postoperative period in each patient. We have compared survivors and non-sur-vivors and assessed the risk factors of mortality. Results. COVID-19 in postoperative period occurred in 31 (4.74%) out of 722 patients. Hypertension (74.2%, n=23) and car-diac diseases including coronary artery disease and chronic heart failure (19.35%, n=6) were the most common comorbidi-ties. Incidence of coronavirus infection was the highest among patients with colorectal cancer (16.13%, n=5), kidney cancer (16.13%, n=5) and lung cancer (12.9%, n=4). We found the following risk factors of mortality in cancer patients with COVID-19: CHD (OR 7.0, 95% CI 1.014-48.313, p