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Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms
R. Gerkin,
K. Ohla,
M. Veldhuizen,
P. Joseph,
C. Kelly,
A. Bakke,
K. Steele,
M. Farruggia,
R. Pellegrino,
M. Pepino,
C. Bouysset,
G. Soler,
V. Pereda-Loth,
M. Dibattista,
K. Cooper,
I. Croijmans,
A. Di Pizio,
M. Ozdener,
A. Fjaeldstad,
C. Lin,
M. Sandell,
P. Singh,
V. Brindha,
S. Olsson,
L. Saraiva,
G. Ahuja,
M. Alwashahi,
S. Bhutani,
A. D’Errico,
M. Fornazieri,
J. Golebiowski,
L. Hwang,
L. Öztürk,
E. Roura,
S. Spinelli,
K. Whitcroft,
F. Faraji,
F. Fischmeister,
T. Heinbockel,
J. Hsieh,
C. Huart,
I. Konstantinidis,
A. Menini,
G. Morini,
J. Olofsson,
C. Philpott,
D. Pierron,
V. Shields,
V. Voznessenskaya,
J. Albayay,
A. Altundag,
M. Bensafi,
M. Bock,
O. Calcinoni,
W. Fredborg,
C. Laudamiel,
J. Lim,
J. Lundström,
A. Macchi,
P. Meyer,
S. Moein,
E. Santamaría,
D. Sengupta,
P. Dominguez,
H. Yanik,
T. Hummel,
J. Hayes,
D. Reed,
M. Niv,
S. Munger,
V. Parma,
S. Boesveldt,
J. de Groot,
C. Dinnella,
J. Freiherr,
T. Laktionova,
S. Marino,
E. Monteleone,
A. Nunez-Parra,
O. Abdulrahman,
M. Ritchie,
T. Thomas-Danguin,
J. Walsh-Messinger,
R. Abri,
R. Alizadeh,
E. Bignon,
E. Cantone,
M. Cecchini,
J. Chen,
M. Guàrdia,
K. Hoover,
N. Karni,
M. Navarro,
A. Nolden,
P. Mazal,
N. Rowan,
A. Sarabi-Jamab,
N. Archer,
B. Chen,
E. Di Valerio,
2021
In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0–10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.
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V. Parma,
K. Ohla,
M. Veldhuizen,
S. Saidov,
N. Smetneva,
S. Davydova,
A. Artemenko,
A. Danilov,
A. Plieva,
Версии
- 1. Version of Record от 2021-01-01
Метаданные
Об авторах
-
R. Gerkin
Arizona State University -
K. Ohla
Forschungszentrum Jülich (FZJ) -
M. Veldhuizen
Mersin Üniversitesi -
P. Joseph
National Institute of Nursing Research (NINR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH) -
C. Kelly
AbScent -
A. Bakke
Pennsylvania State University -
K. Steele
National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) -
M. Farruggia
Yale University -
R. Pellegrino
The University of Tennessee, Knoxville -
M. Pepino
University of Illinois Urbana-Champaign -
C. Bouysset
Université Côte d'Azur -
G. Soler
Grupo de Estudio de Olfato y Gusto (GEOG), Universidad de Buenos Aires -
V. Pereda-Loth
Université Fédérale Toulouse Midi-Pyrénées -
M. Dibattista
Università degli Studi di Bari -
K. Cooper
University of California, Irvine -
I. Croijmans
Utrecht University -
A. Di Pizio
Technical University of Munich -
M. Ozdener
Monell Chemical Senses Center -
A. Fjaeldstad
Hospitalsenheden Vest -
C. Lin
Monell Chemical Senses Center -
M. Sandell
Helsingin Yliopisto -
P. Singh
Universitetet i Oslo -
V. Brindha
Karunya Institute of Technology and Sciences -
S. Olsson
National Centre for Biological Sciences -
L. Saraiva
Sidra Medicine -
G. Ahuja
Indraprastha Institute of Information Technology, Delhi -
M. Alwashahi
Sultan Qaboos University -
S. Bhutani
San Diego State University -
A. D’Errico
Goethe-Universität Frankfurt am Main -
M. Fornazieri
Universidade Estadual de Londrina -
J. Golebiowski
Université Côte d'Azur -
L. Hwang
The University of Queensland -
L. Öztürk
Mersin Üniversitesi -
E. Roura
The University of Queensland -
S. Spinelli
Università degli Studi di Firenze -
K. Whitcroft
UCL Ear Institute -
F. Faraji
UC San Diego Health -
F. Fischmeister
Karl-Franzens-Universitat Graz -
T. Heinbockel
Howard University -
J. Hsieh
Hôpitaux Universitaires de Genève -
C. Huart
Cliniques Universitaires Saint-Luc -
I. Konstantinidis
Aristotle University of Thessaloniki -
A. Menini
Scuola Internazionale Superiore di Studi Avanzati -
G. Morini
Università degli Studi di Scienze Gastronomiche -
J. Olofsson
Stockholms universitet -
C. Philpott
University of East Anglia, Norwich Medical School -
D. Pierron
Université Fédérale Toulouse Midi-Pyrénées -
V. Shields
Towson University -
V. Voznessenskaya
A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences -
J. Albayay
Università degli Studi di Padova -
A. Altundag
Biruni Üniversitesi -
M. Bensafi
Centre de Recherche en Neurosciences de Lyon -
M. Bock
Hospital General Barrio Obrero -
O. Calcinoni
Private Practice -
W. Fredborg
Stockholms universitet -
C. Laudamiel
DreamAir LLC -
J. Lim
Oregon State University -
J. Lundström
Karolinska Institutet -
A. Macchi
Università degli Studi dell'Insubria, Italian Academy of Rhinology -
P. Meyer
IBM Thomas J. Watson Research Center -
S. Moein
Iranian Research Institute for Fundamental Sciences -
E. Santamaría
Clinical Neuroproteomics Unit -
D. Sengupta
Indraprastha Institute of Information Technology, Delhi -
P. Dominguez
Universidad de Extremadura -
H. Yanik
Mersin Üniversitesi -
T. Hummel
Technische Universität Dresden -
J. Hayes
Pennsylvania State University -
D. Reed
Monell Chemical Senses Center -
M. Niv
Hebrew University of Jerusalem -
S. Munger
University of Florida, University of Florida -
V. Parma
Temple University -
S. Boesveldt
Wageningen University & Research -
J. de Groot
Radboud University Nijmegen -
C. Dinnella
Università degli Studi di Firenze -
J. Freiherr
Friedrich-Alexander-Universität Erlangen-Nürnberg -
T. Laktionova
A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences -
S. Marino
Centro de Otorrinolaringología Respira Libre -
E. Monteleone
Università degli Studi di Firenze -
A. Nunez-Parra
Universidad de Chile -
O. Abdulrahman
Federal University of Technology, Akure -
M. Ritchie
University of California, Irvine -
T. Thomas-Danguin
Agrosup Dijon -
J. Walsh-Messinger
University of Dayton -
R. Abri
Sultan Qaboos University -
R. Alizadeh
Iran University of Medical Sciences -
E. Bignon
Université Côte d'Azur -
E. Cantone
Università degli Studi di Napoli Federico II -
M. Cecchini
Università degli Studi di Verona -
J. Chen
The Second Hospital of Xian Jiaotong University -
M. Guàrdia
Institut de Recerca I Technologia Agroalimentaries -
K. Hoover
University of Alaska Fairbanks -
N. Karni
Hadassah University Medical Centre -
M. Navarro
The University of Queensland -
A. Nolden
University of Massachusetts Amherst -
P. Mazal
Instituto Universitario del Hospital Italiano de Buenos Aires -
N. Rowan
Johns Hopkins School of Medicine -
A. Sarabi-Jamab
Iranian Research Institute for Fundamental Sciences -
N. Archer
Commonwealth Scientific and Industrial Research Organization -
B. Chen
Guangzhou Medical University -
E. Di Valerio
University of Florida
Название журнала
- Chemical Senses
Том
- 46
Финансирующая организация
- National Institutes of Health
Номер гранта
- 0109-2018-0079
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
