Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance

P. Koehler; M. Bassetti; A. Chakrabarti; S. Chen; A. Colombo; M. Hoenigl; N. Klimko; C. Lass-Flörl; R. Oladele; D. Vinh; L. Zhu; B. Böll; R. Brüggemann; J. Gangneux; J. Perfect; T. Patterson; T. Persigehl; J. Meis; L. Ostrosky-Zeichner; P. White; P. Verweij; O. Cornely

Статья

Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance

P. Koehler, M. Bassetti, A. Chakrabarti, S. Chen, A. Colombo, M. Hoenigl, N. Klimko, C. Lass-Flörl, R. Oladele, D. Vinh, L. Zhu, B. Böll, R. Brüggemann, J. Gangneux, J. Perfect, T. Patterson, T. Persigehl, J. Meis, L. Ostrosky-Zeichner, P. White, P. Verweij, O. Cornely,

2021

https://doi.org/10.1016/S1473-3099(20)30847-1

Severe acute respiratory syndrome coronavirus 2 causes direct damage to the airway epithelium, enabling aspergillus invasion. Reports of COVID-19-associated pulmonary aspergillosis have raised concerns about it worsening the disease course of COVID-19 and increasing mortality. Additionally, the first cases of COVID-19-associated pulmonary aspergillosis caused by azole-resistant aspergillus have been reported. This article constitutes a consensus statement on defining and managing COVID-19-associated pulmonary aspergillosis, prepared by experts and endorsed by medical mycology societies. COVID-19-associated pulmonary aspergillosis is proposed to be defined as possible, probable, or proven on the basis of sample validity and thus diagnostic certainty. Recommended first-line therapy is either voriconazole or isavuconazole. If azole resistance is a concern, then liposomal amphotericin B is the drug of choice. Our aim is to provide definitions for clinical research and up-to-date recommendations for clinical management of the diagnosis and treatment of COVID-19-associated pulmonary aspergillosis.

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1. Version of Record от 2021-01-01

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P. Koehler
University of Cologne, University of Cologne, Uniklinik Köln
M. Bassetti
Università degli Studi di Genova, Ospedale Policlinico San Martino
A. Chakrabarti
Postgraduate Institute of Medical Education & Research, Chandigarh
S. Chen
Sydney Medical School, Westmead Hospital, The University of Sydney
A. Colombo
Universidade Federal de Sao Paulo
M. Hoenigl
University of California, San Diego, Medizinische Universität Graz
N. Klimko
North-Western State Medical University named after I.I. Mechnikov
C. Lass-Flörl
Medizinische Universitat Innsbruck
R. Oladele
University of Lagos
D. Vinh
L'Institut de Recherche du Centre Universitaire de Santé McGill
L. Zhu
Fudan University
B. Böll
University of Cologne, Uniklinik Köln
R. Brüggemann
Radboud University Nijmegen Medical Centre, Radboud University Nijmegen Medical Centre
J. Gangneux
Centre Hospitalier Universitaire de Rennes
J. Perfect
Duke University Medical Center
T. Patterson
University of Texas Health Science Center at San Antonio, University Health System, South Texas Veterans Health Care System
T. Persigehl
University of Cologne, Uniklinik Köln
J. Meis
Radboud University Nijmegen Medical Centre, Nijmegen Interdenominational Hospital Canisius-Wilhelmina, Universidade Federal do Parana
L. Ostrosky-Zeichner
University of Texas Health Science Center at Houston
P. White
Public Health Wales
P. Verweij
Radboud University Nijmegen Medical Centre, National Institute for Public Health and the Environment
O. Cornely
University of Cologne, University of Cologne, Uniklinik Köln, Medizinische Fakultät, Universität Bonn

Название журнала

The Lancet Infectious Diseases

Финансирующая организация

U.S. Department of Defense

Номер гранта

EXC 2030— 390661388

Тип документа

journal article

Тип лицензии Creative Commons

CC BY

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scopus

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Статья

Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance

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