Main drugs used to treat COVID-19 and its complications are reviewed. Brief information about the molecular mechanisms of action of etiotropic, pathogenetic and symptomatic palliative drugs is given. A comparative analysis of data available on the efficacy and safety of drugs and the risks of drug interactions is carried out. There are currently no proven effective treatments for COVID-19. Rapidly expanding knowledge about the nature of SARS-CoV-2 is creating conditions for increase in the number of potential drug targets for the treatment of COVID-19.