Статья

Nitric oxide-releasing compounds for the treatment of lung infections

L. Chiarelli, G. Degiacomi, A. Egorova, V. Makarov, M. Pasca,
2021

The spread of acquired drug resistance and of microorganisms naturally resistant to antibiotics is a major threat to global health, leading to an urgent need for novel antimicrobial compounds. Exogenous nitric oxide (NO) represents an attractive and promising antimicrobial approach, showing both bactericidal and biofilm dispersal activities. Numerous studies have been performed to develop NO donor scaffolds, including small molecules, macromolecular compounds, nanoparticles (NPs), and polymeric materials. This approach has resulted in successful outcomes, with some NO-releasing compounds entering clinical practice. In this review, we highlight the importance of this strategy, with a focus on lung infections.

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  • 1. Version of Record от 2021-02-01

Метаданные

Об авторах
  • L. Chiarelli
    Università degli Studi di Pavia
  • G. Degiacomi
    Università degli Studi di Pavia
  • A. Egorova
    Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences
  • V. Makarov
    Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences
  • M. Pasca
    Università degli Studi di Pavia
Название журнала
  • Drug Discovery Today
Том
  • 26
Выпуск
  • 2
Страницы
  • 542-550
Финансирующая организация
  • Cystic Fibrosis Foundation
Номер гранта
  • 14/2020
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus