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Статья
Нейтрофилы являются «первой линией» защиты от патогенов в очаге воспаления, где они используют такие эффекторные функции, как фагоцитоз, дегрануляцию и образование активных форм кислорода (АФК). В 2004 г. Артуро Циклински охарактеризовал еще одну эффекторную функцию нейтрофилов – выброс нейтрофильных внеклеточных ловушек, или NET (neutrophil extracellular traps). NET представляют собой модифицированный хроматин, «декорированный» бактерицидными белками гранул, ядра и цитоплазмы. Выброс NET может активироваться разнообразными физиологическими и фармакологическими стимулами и зависит от АФК, основным источником которых является NADPH-оксидаза. В процессе активации NET происходят выход бактерицидных компонентов гранул в цитоплазму, модификация гистонов, ведущая к деконденсации хроматина, разрушение ядерной оболочки и цитоплазматической мембраны при участии белка газдермина D и, наконец, выброс хроматина за пределы клетки. Вместе с тем, неконтролируемое образование NET является провоцирующим фактором развития многих воспалительных и аутоиммунных заболеваний. NET были обнаружены при таких аутоиммунных заболеваниях, как системная красная волчанка, ревматоидный артрит, псориаз и васкулиты; NET участвуют в патогенезе сердечно-сосудистых, легочных и онкологических заболеваний. В настоящем обзоре обсуждаются основные представления о механизмах образования NET, а также их роль в физиологических процессах и патогенезе ряда заболеваний, включая COVID-19.
Цитирование
Список литературы
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Версии
- 1. Version of Record от 2020-11-05
Метаданные
Об авторах
Предметная рубрика
- COVID-19
Название журнала
- Vestnik Moskovskogo universiteta. Seriya 16. Biologiya
Страницы
- 210-225
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- elpub
