COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity

E. Verbitskiy, S. Baskakova, D. Belyaev, D. Vakhrusheva, N. Eremeeva, G. Rusinov, V. Charushin,
2021
https://doi.org/10.1016/j.mencom.2021.03.021

The Buchwald–Hartwig cross-coupling of 5-bromo-4-(furan-2-yl)pyrimidine with various anilines afforded the corresponding new 5-(arylamino)pyrimidines, the reaction being accelerated by microwave irradiation. Most of the obtained compounds proved to possess a high bacteriostatic in vitro effect against Mycobacterium tuberculosis H Rv, Neisseria gonorrhoeae, and Staphylococcus aureus including Methicillin-resistant strain, which is stronger than that of the commercial drug Spectinomycin. 37

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Документы

Источник

Версии

  • 1. Version of Record от 2021-03-01

Метаданные

Об авторах
  • E. Verbitskiy
    Postovsky Institute of Organic Synthesis of Ural Division of Russian Academy of Sciences, Ural Federal University
  • S. Baskakova
    Postovsky Institute of Organic Synthesis of Ural Division of Russian Academy of Sciences
  • D. Belyaev
    Postovsky Institute of Organic Synthesis of Ural Division of Russian Academy of Sciences, Ural Research Institute for Phthisiopulmonology - the Branch of the National Medical Research Center for Phthisiopulmology and Infectious Diseases under the Ministry of Health of the Russian Federation
  • D. Vakhrusheva
    Ural Research Institute for Phthisiopulmonology - the Branch of the National Medical Research Center for Phthisiopulmology and Infectious Diseases under the Ministry of Health of the Russian Federation
  • N. Eremeeva
    Ural Research Institute for Phthisiopulmonology - the Branch of the National Medical Research Center for Phthisiopulmology and Infectious Diseases under the Ministry of Health of the Russian Federation
  • G. Rusinov
    Postovsky Institute of Organic Synthesis of Ural Division of Russian Academy of Sciences, Ural Federal University
  • V. Charushin
    Postovsky Institute of Organic Synthesis of Ural Division of Russian Academy of Sciences, Ural Federal University
Название журнала
  • Mendeleev Communications
Том
  • 31
Выпуск
  • 2
Страницы
  • 210-212
Финансирующая организация
  • Ministry of Education and Science of the Russian Federation
Номер гранта
  • 075-15-2020-777
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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