Complex mechanism of COVID-19 development

Болевич С. Б.; Болевич C. C.

Статья

Комплексный механизм развития СOVID-19

Болевич С. Б.,

Болевич C. C.,

2020

https://doi.org/10.47093/2218-7332.2020.11.2.50-61

Коронавирусная инфекция (COVID-19) — острое вирусное заболевание с поражением всех жизненно важных органов, вызываемое РНК-геномным вирусом рода Betacoronavirus семейства Coronaviridae. SARS-CoV-2 попадает в организм через дыхательные пути и взаимодействует в первую очередь с Толл-рецепторами (TLR) эпителиальных клеток бронхов, альвеол, кишечника и эндотелиоцитов сосудов, а также с рецепторами ангиотензинпревращающего фермента 2. TLR активируют в данных клетках ядерный фактор каппа В (NF-κB), который, в свою очередь, инициирует образование в большом количестве цитокинов («цитокиновая буря»). SARS-CoV-2, поражая пневмоциты II типа, вызывает прекращение образования сурфактанта и, соответственно, сморщивание альвеол и возникновение острого респираторного дистресс-синдрома, а также образование фиброза на альвеолярно-капиллярной мембране и возникновение острой дыхательной недостаточности. SARS-CoV-2 и цитокины нарушают функцию эндотелиальных клеток сосудов, что приводит к возникновению эндотелиальной дисфункции. В микрососудах происходит массовое образование микротромбов, что вызывает нарушение функции органов и систем. «Цитокиновая буря» переходит в цитокиновый сепсис с возникновением синдрома полиорганной недостаточности.

Цитирование

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1. Version of Record от 2020-12-04

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Об авторах

Болевич С. Б.
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Болевич C. C.
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)

Предметная рубрика

COVID-19

Название журнала

Sechenov Medical Journal

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50-61

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journal article

Тип лицензии Creative Commons

CC BY

Правовой статус документа

Свободная лицензия

Источник

elpub

Поиск по репозиторию

Статья

Комплексный механизм развития СOVID-19

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