The article explores transformation of EU party-political space and the changing patterns of inter-parliamentary interaction in the European Parliament after 2019 EP elections. The article explores basic characteristics of EU party-political space. It concludes that a two-dimensional space of political self identification has emerged in the European Parliament: the classical right-left axis is supplemented by a properly formed axis ―supporters of deeper integration - eurosceptics''. It demonstrates that the formation of a stable axis ―supporters of deeper integration - eurosceptics'' leads to the erosion of the traditional consensus culture in the EP. The more complex EP political landscape leads to greater flexibility. Instead of stable unions, various ad hoc issue driven coalitions will play an increasing role in the EP. Given the new balance of power between pro-integration and eurosceptic parties, the European Parliament is unlikely to be able to play the traditional role of the EU's most pro-integration institution; its ability to influence the legislative and political process in the EU will decrease.