COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Recombinant SARS-CoV-2 S Protein Binds to Glycans of the Lactosamine Family in vitro

A. Ryzhikov, G. Onkhonova, I. Imatdinov, E. Gavrilova, R. Maksyutov, E. Gordeeva, G. Pazynina, I. Ryzhov, N. Shilova, N. Bovin,
2021
https://doi.org/10.1134/S0006297921030019

Abstract: Many viruses, beside binding to their main cell target, interact with other molecules that promote virus adhesion to the cell; often, these additional targets are glycans. The main receptor for SARS-CoV-2 is a peptide motif in the ACE2 protein. We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family. We suggest that parallel influenza infection will promote SARS-CoV-2 adhesion to the respiratory epithelial cells due to the unmasking of lactosamine chains by the influenza virus neuraminidase.

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Документы

Источник

Версии

  • 1. Version of Record от 2021-03-01

Метаданные

Об авторах
  • A. Ryzhikov
    State Research Center of Virology and Biotechnology VECTOR
  • G. Onkhonova
    State Research Center of Virology and Biotechnology VECTOR
  • I. Imatdinov
    State Research Center of Virology and Biotechnology VECTOR
  • E. Gavrilova
    State Research Center of Virology and Biotechnology VECTOR
  • R. Maksyutov
    State Research Center of Virology and Biotechnology VECTOR
  • E. Gordeeva
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  • G. Pazynina
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  • I. Ryzhov
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  • N. Shilova
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Nationa Medical Research Center Obsterics, Gynecology and Perinatology the name of Academician V.I. Kulakov
  • N. Bovin
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Название журнала
  • Biochemistry (Moscow)
Том
  • 86
Выпуск
  • 3
Страницы
  • 243-247
Финансирующая организация
  • Russian Foundation for Basic Research
Номер гранта
  • 20-04-60335
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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