Objective: to present data and analyze current data on diagnostics of acute skin failure in children. The term “acute skin failure” is rarely used in the literature. Among the works published in Russian, we found only one study of our colleagues from the Republic of Belarus, where we met the definition and description of this term. When searching the Pubmed database, we found 58 scientific works, only 7 of them were devoted to children. When determining the presence or absence of multiple organ failure syndrome, none of the scales used for adults and children included skin disorders. The majority of scales described changes in the respiratory system, kidneys, liver, cardiovascular system, neurological status and blood system. However, acute skin failure is a serious problem similar to insufficiency of internal organs. The clinical case demonstrates the possibility of effective intensive care in a child with acute skin failure. We believe that the diagnosis of acute skin failure as a primary or secondary component of multiple organ failure syndrome in children in the intensive care unit is an important step towards the correct and adequate treatment of such patients.