Epidemics, natural disasters, serious illness and life misery are a serious test for human mental and physical well-being. Studies have shown significant benefits of religious or spiritual life for people’s health and welfare. There is evidence that religious and spiritually oriented patients are more stress resistant, tolerant of pain, less prone to depression, and more committed to on-going treatment and a healthy lifestyle. However, the number and quality of studies performed are limited. This is due to a frequent distinction lack between concepts of religiosity and spirituality (R/S), patients’ attitude heterogeneity, unexplored mechanisms of religious and spiritual influence on human health and insufficient research method standardisation. Very promising is introducing spiritually oriented techniques in the healthcare system. It is advisable to train outpatient medical personnel and clergymen in such technique intervention. More R/S impact research on human well-being and health is needed as it is the basis for this kind of practice further improvement.