The article provides information on changes in the activity of centers of public health and medical prevention in conditions of CO-VID-19 pandemic. Examples of response to the coronavirus outbreak of the world medical community are given, the developed strategies and the most effective restrictive measures are listed. The result of a survey of 72 regions of the Russian Federation on changes in the work of public health and medical prevention centers that have occurred since the announcement of the pandemic and the establishment of the Coronavirus operation headquarters is presented. The information about the development of new information materials, speeches in mass media, holding online events and live broadcasts for patients, providing medical and psy-chological assistance to the population at home and on the phone, organizing methodological assistance to medical organizations on the prevention of risk factors for chronic non-communicable diseases in COVID-19 conditions is listed. Receiving new data on changes in the work of different spheres of health care system during the global pandemic will allow developing new algorithms of response in such situations and optimizing the functions of public health and medical prevention centers.