Purpose. To study the characteristics of responding to a current stressful situation caused by the COVID-19 pandemic of various contingents of the population, including medical workers who do not work directly with COVID-19 patients. Materials and methods. 132 respondents were surveyed online. The questionnaire included biometric indicators, questions for evaluating the relevance to the COVID-19 pandemic, and the Spielberger-Hanin scale. For statistical analysis, the Kruskal-Wallis test, the Mann-Whitney U test, and Pearson χ2 were used. Depending on the field of activity, all respondents were divided into 4 groups: Health professionals working in another field, those receiving education, and people without permanent employment. Results. The changes were recorded in the general sample, indicating the increase of the level of anxiety due to the current stressful situation. Statistically significant intergroup differences were revealed (with significance level p≤0.05) in terms of constitutional and situational anxiety reflecting the current state of the individual: Respondents with a high level of personal anxiety were found more often in the groups of healthcare professionals and those receiving education than among the other two groups; they also registered the increase of the level of situational anxiety to high rates, quantitatively most pronounced in the group of health workers (for the majority), qualitatively in those receiving education, where 1/3 of the respondents recorded extremely high, clinically significant levels. Whereas in the other 2 groups there was an opposite tendency-to react with low levels of situational anxiety in a significant part of cases. Conclusion. Medical workers and educators are the most vulnerable population in terms of overresponse to stressful situations. Extremely high levels of situational anxiety were revealed in 15% of medical workers and in 34% of educated people. It indicates that they are in the state of distress and the need for a more detailed examination to identify possible borderline mental pathology with the organization of psychological and psychotherapeutic support.