Blood purification methods are widely used for sepsis, systemic inflammatory response and multiple organ failure. The new coro-navirus infection followed by sepsis or septic shock in severe cases is characterized by imbalance in concentrations of pro-and an-ti-inflammatory mediators (the so-called cytokine storm). These processes result the development and progression of multiple organ failure. Special attention is paid to impaired renal function, since acute renal damage in COVID-19 is a predictor of an ad-verse outcome. In this situation, blood purification methods are advisable for discontinuation of cytokine storm on the one hand and treatment/prevention of acute kidney injury on the other one. The authors describe blood purification methods which are cur-rently used in the treatment of sepsis and septic shock and can be used for COVID-19. Effectiveness of some of these techniques have been already confirmed. The issues of acute renal injury and options for renal replacement therapy are also considered.