The authors carried out a systematic analysis of the data available in the modern literature on the effect of different types of vaccines on the male and female reproductive system. The review includes data from publications presented in the PubMed database (https://pubmed.ncbi.nlm.nih.gov/) on this topic. It gives information on the types of vaccines. The paper describes possible adverse events (AEs) due to vaccine administration, as well as the development of autoimmune diseases and AEs associated with the effect of antibody-dependent enhancement. Particular attention is paid to the analysis of the available data on the effect of different types of vaccines, including coronavirus vaccines, on the reproductive system of mammals, including humans, and the genesis of their occurrence, in particular the autoimmune-mediated mechanism of damage to the reproductive organs. Conclusion. Taking into account that the literature does not describe a single prospective study that would investigate the effect of vaccines on human reproductive function, or data on the possible negative effect of vaccines are conjectural or based on the follow-up findings in patients without prior examination of their reproductive status, it is necessary to conduct further investigations of the effect of different types of vaccines on reproductive function.