The COVID-19 pandemic has become a serious challenge to socio-economic, political and cultural spheres around the world. In some cases, the disease occurs with disorders in the hemostatic system and the development of coagulopathies, but today there is no data on the effect of SARS-CoV-2 on microcirculation indicators. Objective. Study of microcirculation parameters in patients who underwent COVID-19. Material and methods. Patients for the study were selected at the clinical bases of outpatient clinics in Samara in the period May— June 2020. The study included 121 patients (group 1, main) who underwent COVID-19 (the diagnosis was verified and confirmed by laboratory polymerase chain reaction in the study of biological material). The control group n=33 (group 2) included persons comparable to patients of group 1 in terms of gender and age characteristics, who didn’t have COVID-19 in anamnesis. The parameters of microcirculation were evaluated using the method of laser Doppler flowmetry of skin vessels (LDF) on a laser blood microcirculation analyzer for a General practitioner LAKK-OP (LLC scientific and production enterprise «Lazma», Moscow, 2010). Results. The average age of patients who underwent COVID-19 was 49.5±18.7 years, 61.2% were men. The majority of patients (52.1%) were between the ages of 18 and 44, and only 15.7% were 65 years of age or older. The majority of patients 76.0% nev-er smoked. The main complaints are fatigue/General weakness (78.6%), fever (74.5%), difficulty breathing/shortness of breath (46.9%), cough (42.9%), headaches (39.8%), loss of smell and/or taste (31.6%), digestive disorders (25.5%), rhinitis and/or throat inflammation (13.3%). In 1 group — there was a statistically significant decrease in the perfusion index and the coefficient of vari-ation of microcurrent with a simultaneous increase in the blood flow reserve in the group of people who underwent COVID-19, compared with the control group. The obtained data indicate a decrease in perfusion and activity of microcurrent regulation pro-cesses in 1 group. A significant decrease in the normalized value of microcurrent oscillation amplitudes associated with neuro-genic, myogenic and endothelial regulation was revealed. Conclusion. Significant changes in the level of microcirculation were registered in patients who underwent COVID-19, which is unfavorable for the prognosis and requires the development of preventive measures aimed at reducing the risk of thrombosis. Additional prevention strategies are needed for patients who have undergone COVID-19 to address the factors that lead to micro-vascular and macrovascular thrombosis.