The number of COVID-19 patients is increasing worldwide and the number of patients with neurological manifestations of a new coronavirus infection is increasing as well. Pathognomonic for COVID-19 is the presence of cephalgic syndrome, infec-tious-toxic encephalopathy, hypo-and anosmia and ageusia. Inducing of pathological autoimmune response contributes to the development of Miller Fischer and Guillain—Barré syndrome. Hyperergic reaction with the generation of the so-called «cytokine storm» provokes multisystem hemorrhagic complications such as Kawasaki disease and acute necrotizing hemorrhagic enceph-alopathy. There is also a special form of COVID-19-associated stroke. Almost all post-COVID-19 patients complain of severe fa-tigue, emotional lability, and sometimes have features of asthenic-neurotic, anxiety-phobic disorders and apato-abulic syndromes, which require rehabilitation measures, as well as courses of restorative neurotrophic and nootropic therapy.