The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world. Although some progress has been made in understanding the viral structure and invasion mechanism of coronaviruses that may cause severe syndrome, due to the limited understanding of the immune effects caused by SARS-CoV-2, it is difficult for us to prevent patients from developing the acute respiratory distress syndrome (ARDS) and syndrome of cytokines storm, the major complications of coronavirus infection. In this review, we summarized immune responses to SARS-CoV-2 and described some mechanism of evasion from immune system. This may provide clue of using immune therapy as combine treatment to prevent the patient develop into ARDS and largely reduced complications.