Статья

Prospects of and barriers to the development of epitope-based vaccines against human metapneumovirus

E. Stepanova, V. Matyushenko, L. Rudenko, I. Isakova-Sivak,
2020

Human metapneumovirus (HMPV) is a major cause of respiratory illnesses in children, the elderly and immunocompromised patients. Although this pathogen was only discovered in 2001, an enormous amount of research has been conducted in order to develop safe and effective vaccines to prevent people from contracting the disease. In this review, we summarize current knowledge about the most promising experimental B-and T-cell epitopes of human metapneumovirus for the rational design of HMPV vaccines using vector delivery systems, paying special attention to the conservation of these epitopes among different lineages/genotypes of HMPV. The prospects of the successful development of an epitope-based HMPV vaccine are discussed in the context of recent findings regarding HMPV’s ability to modulate host immunity. In particular, we discuss the lack of data on experimental human CD4 T-cell epitopes for HMPV despite the role of CD4 lymphocytes in both the induction of higher neutralizing antibody titers and the establishment of CD8 memory T-cell responses. We conclude that current research should be focused on searching for human CD4 T-cell epitopes of HMPV that can help us to design a safe and cross-protective epitope-based HMPV vaccine.

Цитирование

Похожие публикации

Источник

Версии

  • 1. Version of Record от 2020-06-01

Метаданные

Об авторах
  • E. Stepanova
    Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences
  • V. Matyushenko
    Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences
  • L. Rudenko
    Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences
  • I. Isakova-Sivak
    Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences
Название журнала
  • Pathogens
Том
  • 9
Выпуск
  • 6
Страницы
  • 1-20
Финансирующая организация
  • Russian Science Foundation
Номер гранта
  • 17-75-20054
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus