Статья

Antibodies to highly pathogenic A/H5Nx (Clade 2.3.4.4) influenza viruses in the sera of vietnamese residents

T. Ilyicheva, V. Marchenko, O. Pyankova, A. Moiseeva, T. Nhai, B. Lan Anh, T. Sau, A. Kuznetsov, A. Ryzhikov, R. Maksyutov,
2021

To cause a pandemic, an influenza virus has to overcome two main barriers. First, the virus has to be antigenically new to humans. Second, the virus has to be directly transmitted from humans to humans. Thus, if the avian influenza virus is able to pass the second barrier, it could cause a pandemic, since there is no immunity to avian influenza in the human population. To determine whether the adaptation process is ongoing, analyses of human sera could be conducted in populations inhabiting regions where pandemic virus variant emergence is highly possible. This study aimed to analyze the sera of Vietnamese residents using hemagglutinin inhibition reaction (HI) and microneutralization (MN) with A/H5Nx (clade 2.3.4.4) influenza viruses isolated in Vietnam and the Russian Federation in 2017-2018. In this study, we used sera from 295 residents of the Socialist Republic of Vietnam collected from three groups: 52 samples were collected from households in Nam Dinh province, where poultry deaths have been reported (2017); 96 (2017) and 147 (2018) samples were collected from patients with somatic but not infectious diseases in Hanoi. In all, 65 serum samples were positive for HI, at least to one H5 virus used in the study. In MN, 47 serum samples neutralizing one or two viruses at dilutions of 1/40 or higher were identified. We postulate that the rapidly evolving A/H5Nx (clade 2.3.4.4) influenza virus is possibly gradually adapting to the human host, insofar as healthy individuals have antibodies to a wide spectrum of variants of that subtype.

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  • 1. Version of Record от 2021-04-01

Метаданные

Об авторах
  • T. Ilyicheva
    State Research Center of Virology and Biotechnology VECTOR, Novosibirsk State University
  • V. Marchenko
    State Research Center of Virology and Biotechnology VECTOR
  • O. Pyankova
    State Research Center of Virology and Biotechnology VECTOR
  • A. Moiseeva
    State Research Center of Virology and Biotechnology VECTOR
  • T. Nhai
    Russian-Vietnamese Tropical Research and Technology Centre
  • B. Lan Anh
    Russian-Vietnamese Tropical Research and Technology Centre
  • T. Sau
    Russian-Vietnamese Tropical Research and Technology Centre
  • A. Kuznetsov
    Russian-Vietnamese Tropical Research and Technology Centre
  • A. Ryzhikov
    State Research Center of Virology and Biotechnology VECTOR
  • R. Maksyutov
    State Research Center of Virology and Biotechnology VECTOR
Название журнала
  • Pathogens
Том
  • 10
Выпуск
  • 4
Номер гранта
  • undefined
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus