COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Light and corona: guided-wave readout for coronavirus spike protein–host-receptor binding

I. Fedotov, Z. Yi, A. Voronin, A. Svidzinsky, K. Sower, X. Liu, E. Vlasova, T. Peng, X. Liu, S. Moiseev, V. Belousov, A. Sokolov, M. Scully, A. Zheltikov,
2020
https://doi.org/10.1364/OL.402897

We show that waveguide sensors can enable a quantitative characterization of coronavirus spike glycoprotein–hostreceptor binding—the process whereby coronaviruses enter human cells, causing disease. We demonstrate that such sensors can help quantify and eventually understand kinetic and thermodynamic properties of viruses that control their affinity to targeted cells, which is known to significantly vary in the course of virus evolution, e.g., from SARS-CoV to SARS-CoV-2, making the development of virus-specific drugs and vaccine difficult. With the binding rate constants and thermodynamic parameters as suggested by the latest SARS-CoV-2 research, optical sensors of SARS-CoV-2 spike protein–receptor binding may be within sight.

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Источник

Версии

  • 1. Version of Record от 2020-10-01

Метаданные

Об авторах
  • I. Fedotov
    Texas A&M University, Lomonosov Moscow State University, National University of Science & Technology (MISIS), Kazan National Research Technical University named after A. N. Tupolev -KAI
  • Z. Yi
    Texas A&M University
  • A. Voronin
    Lomonosov Moscow State University, National University of Science & Technology (MISIS), Kazan National Research Technical University named after A. N. Tupolev -KAI
  • A. Svidzinsky
    Texas A&M University
  • K. Sower
    Texas A&M University
  • X. Liu
    Texas A&M University
  • E. Vlasova
    National University of Science & Technology (MISIS)
  • T. Peng
    Texas A&M University
  • X. Liu
    Texas A&M University, University of Science and Technology of China
  • S. Moiseev
    Kazan National Research Technical University named after A. N. Tupolev -KAI
  • V. Belousov
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Federal Medical Biological Agency of Russia
  • A. Sokolov
    Texas A&M University, Baylor University
  • M. Scully
    Texas A&M University, Baylor University, Princeton University
  • A. Zheltikov
    Texas A&M University, Lomonosov Moscow State University, National University of Science & Technology (MISIS), Kazan National Research Technical University named after A. N. Tupolev -KAI
Название журнала
  • Optics Letters
Том
  • 45
Выпуск
  • 19
Страницы
  • 5428-5431
Финансирующая организация
  • Welch Foundation
Номер гранта
  • A-1547
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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