The authors explore the nature of the transformation of the main public institutions under a pandemic, focusing on the analysis of changes in the system of socio-economic relations. It is noted that the first symptoms of the global crisis arose before the pandemic and were further intensified. Based on the first empirical data on the consequences of the pandemic, the thesis is proved, developed by authors earlier, that market coordination relations are substantially complemented directly by public regulation. Changes in property relations and relevant contradictions in labor relations are revealed. The interests of various social strata and new impulses of income redistribution, reducing inequality, solidarity, and transformation in the system of values and motivation of the person are shown. A number of measures in the field of socio-economic policy and reforming institutions aimed at developing an optimal strategy for overcoming the crisis are proposed.