Objective of the research: to assess the prevalence and course of COVID-19 in children and adolescents with cystic fibrosis (CF) in the Russian Federation. Materials and methods: up to September 1, 2020, 10 cases of COVID-19 in CF patients were registered. Results: the incidence of COVID-19 among children and adolescents with CF up to September 1, 2020 was 3,4:1000. Asymptomatic course was noted in 3 children, mild – in 5, moderate – in 2 (20%) with pneumonia. The main symptoms were fiver (60% – 6 children), increased cough – 5 (50%) and fatigue – in 3 children (30%), in 2 patients (20%) abdominal syndrome. All patients received dornase alfa inhalations, two patients received azythromycin for anti-inflammatory purposes and permanent antibacterial therapy. These factors may play a role in the milder course of COVID-19 in children and adolescents with CF.