Objective of the research: to analyze clinical and laboratory manifestations of COVID-19 with a predominant lesion of the gastrointestinal tract (GIT) in children. It was revealed that incidence of this form of COVID-19 in children is underestimated. Based on the analysis of literature data and original clinical observations, the article describes current ideas about the frequency of detecting the form of COVID-19 with a predominant lesion of the GIT, its clinical and laboratory characteristics, the mechanisms of infectious process development in the digestive organs and approaches to rational laboratory diagnostics. The feasibility of PCR in feces in patients with suspected COVID-19 is confirmed. A description of a clinical case of COVID-19 severe form, which required differential diagnosis with acute bacterial gastroenterocolitis, is presented.