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Статья
Convalescent plasma therapy of a new coronavirus infection: An experience of Moscow city hospitals
2020
An actual current problem is therapy of a new coronavirus infection. An important feature of COVID-19 pandemic is the absence of standard therapy. All available remedies are experimental. Considering the experience of previous viral pandemics, we can as-sume the effect of convalescent plasma therapy of COVID-19 infection. In this manuscript, we have analyzed an experience of convalescent plasma therapy of COVID-19 infection plasma in the Moscow city hospitals. Objective. To analyze the first experience of convalescent plasma therapy of a new coronavirus infection in the Moscow city hos-pitals. Material and methods. Fresh frozen plasma (FFP) obtained by apheresis and subjected to pathogen reduction was transfused to 226 patients with moderate-to-severe COVID-19 infection. The control group retrospectively included 226 patients with similar characteristics. Results. We found significantly reduced mortality after 10 (5.3 vs 17.2%) and 28 days (14.2 vs 50%) in the main group. These differences were more significant for patients who did not require mechanical ventilation (relative risk of death 0.369, 95% CI 0.159-0.859). Conclusion. Convalescent plasma therapy is effective for COVID-19 infection. In particular, this approach is advisable in patients with significant respiratory failure and no need for mechanical ventilation.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2020-12-01
Метаданные
Название журнала
- Russian Journal of Anesthesiology and Reanimatology
Том
- 6
Выпуск
- 2
Страницы
- 33-39
Номер гранта
- undefined
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
