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Статья
Stereoselective synthesis of unnatural α-amino acid derivatives through photoredox catalysis
2021
A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived N-sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing a convenient method for the synthesis of unnatural α-amino acids. The developed protocol allows the use of ubiquitous carboxylic acids as radical precursors without prior derivatization. The protocol utilizes near-stoichiometric amounts of the imine and the acid radical precursor in combination with a catalytic amount of an organic acridinium-based photocatalyst. Alternative mechanisms for the developed transformation are discussed and corroborated by experimental and computational studies.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-21
Метаданные
Название журнала
- Chemical Science
Том
- 12
Выпуск
- 15
Страницы
- 5430-5437
Финансирующая организация
- Tomsk Polytechnic University
Номер гранта
- 203\2020
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY
Правовой статус документа
- Свободная лицензия
Источник
- scopus
