Статья

From Myo-inositol to D-chiro-inositol molecular pathways

A. KIANI, S. PAOLACCI, A. CALOGERO, R. CANNARELLA, G. DI RENZO, S. GERLI, C. DELLA MORTE, G. BUSETTO, E. DE BERARDINIS, F. DEL GIUDICE, L. STUPPIA, F. FACCHINETTI, S. DINICOLA, M. BERTELLI,
2021

OBJECTIVE: Inositol is a carbocyclic sugar polyalcohol. By epimerization of its hydroxyl groups, nine possible stereoisomers can be generated, two of major physiological and clinical relevance: Myo-inositol and D-chiro-inositol. Myo-inositol and D-chiro-inositol are normally stored in kidney, brain and liver and are necessary for functions, such as signal transduction, metabolic flux, insulin signaling, regulation of ion-channel permeability, stress response and embryo development. In this narrative review, we summarize the mechanisms by which myo-inositol and D-chiro-inositol can be synthesized and absorbed and their possible role in the etiopathogenesis of neural tube defects. MATERIALS AND METHODS: We performed an online search in the PubMed database using the following keywords: "inositol", "D-chiro-inositol", "myo-inositol", "neural tube defects and inositol". RESULTS: Inositol requirements are partly met by dietary intake, while the rest is synthesized endogenously. Inositol deficiency may be involved in the pathogenesis of diseases, such as metabolic syndrome, spina bifida (a neural tube defect), polycystic ovary syndrome and diabetes. Supplementation of the two inositol stereoisomers, D-chiro-inositol and myo-inositol is important to prevent these conditions. CONCLUSIONS: Inositol is fundamental for signal transduction in the brain, kidneys, reproductive organs and other tissues in response to neurotransmitters, hormones and growth factors. Various genes are involved in inositol metabolism and associated pathways. Altered inositol concentrations are observed in several diseases. Analysis of the genes involved in inositol metabolism may provide important information for the clinical management of these conditions.

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  • 1. Version of Record от 2021-01-01

Метаданные

Об авторах
  • A. KIANI
    MAGI Euregio Scs
  • S. PAOLACCI
    MAGI's Lab
  • A. CALOGERO
    Università degli Studi di Catania
  • R. CANNARELLA
    Università degli Studi di Catania
  • G. DI RENZO
    Università degli Studi di Perugia, Lomonosov Moscow State University
  • S. GERLI
    Università degli Studi di Perugia
  • C. DELLA MORTE
    Università degli Studi di Perugia
  • G. BUSETTO
    Sapienza Università di Roma
  • E. DE BERARDINIS
    Sapienza Università di Roma
  • F. DEL GIUDICE
    Sapienza Università di Roma
  • L. STUPPIA
    University of G. d'Annunzio Chieti and Pescara
  • F. FACCHINETTI
    Università degli Studi di Modena e Reggio Emilia
  • S. DINICOLA
    Sapienza Università di Roma
  • M. BERTELLI
    MAGI Euregio Scs, MAGI's Lab, EBTNA-LAB
Название журнала
  • European Review for Medical and Pharmacological Sciences
Том
  • 25
Выпуск
  • 5
Страницы
  • 2390-2402
Номер гранта
  • undefined
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus