Possible zinc deficiency in the Serbian population: examination of body fluids, whole blood and solid tissues

J. Jagodić, B. Rovčanin, S. Borković-Mitić, L. Vujotić, V. Avdin, D. Manojlović, A. Stojsavljević,

Studies indicate that the soil, water and consequently foodstuffs in Serbia are significantly poor in zinc (Zn), and thus, it is likely that there is a Zn deficiency in the Serbian population. This study examined the Zn status in multiple clinical samples, including body fluids (serum, cerebrospinal fluid), whole blood and Zn-rich solid tissues (thyroid and brain tissue). Differences between sex and age were also considered, and comparative analysis of Zn status with other world populations was performed. Serum samples from a large number of Serbian adults approximately had twofold lower Zn amounts when compared to other populations. A similar trend was obtained for whole blood. Males had significantly higher amounts of Zn in serum, whole blood and thyroid tissue samples than females. Higher amounts of Zn were observed in the group older than 50 years. Importantly, in thyroid and brain tissues, Zn was 10- and 20-fold lower, respectively, than reported in the literature. Our results indicate that the population in Serbia could be considered Zn deficient. Therefore, adequate oral Zn supplementation and/or foodstuff fortification should be considered to prevent the deleterious effects caused by Zn deficiency.





  • 1. Version of Record от 2021-01-01


Об авторах
  • J. Jagodić
    University of Belgrade, Faculty of Chemistry
  • B. Rovčanin
    University of Belgrade, Klinicki Centar Srbije
  • S. Borković-Mitić
    University of Belgrade
  • L. Vujotić
    University of Belgrade
  • V. Avdin
    South Ural State University
  • D. Manojlović
    University of Belgrade, Faculty of Chemistry, South Ural State University
  • A. Stojsavljević
    University of Belgrade, Faculty of Chemistry, University of Belgrade, Faculty of Chemistry
Название журнала
  • Environmental Science and Pollution Research
Финансирующая организация
  • Ministry of Education, Science and Technology
Номер гранта
  • undefined
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY
Правовой статус документа
  • Свободная лицензия
  • scopus